Building an Infrastructure Level Context Model in Ambient Assisted Living

Ambient Assisted Living (AAL) services provide intelligent and context aware assistance for elderly people in their home environment. This domain puts special requirements on context modeling that are not in the scope of current context modeling approaches. Such an approach has to support all phases of an AAL service, from its specification and development until its operation within the user’s smart home environment. In these phases different types of context models can be identified. We have developed a comprehensive context modeling approach for the development of AAL services. Part of it is the separation of context modeling into infrastructure, service adaptation and end user modeling specific aspects. In this paper we focus on the infrastructure, which includes the context sensors available in the smart home environment. Therein we present our context modeling approach starting from a conceptual context model. We also introduce a context management system based on a metamodel that supports its seamless transition into an operative context model without further implementation

Building an Infrastructure Level Context Model in Ambient Assisted Living

Ambient Assisted Living (AAL) services provide intelligent and context aware assistance for elderly people in their home environment. This domain puts special requirements on context modeling that are not in the scope of current context modeling approaches. Such an approach has to support all phases of an AAL service, from its specification and development until its operation within the user’s smart home environment. In these phases different types of context models can be identified. We have developed a comprehensive context modeling approach for the development of AAL services. Part of it is the separation of context modeling into infrastructure, service adaptation and end user modeling specific aspects. In this paper we focus on the infrastructure, which includes the context sensors available in the smart home environment. Therein we present our context modeling approach starting from a conceptual context model. We also introduce a context management system based on a metamodel that supports its seamless transition into an operative context model without further implementation

Building a COVID-Safe Navigation App Using a Meta-Model Based Context Server

Building context-aware applications is an already widely researched topic. It is our belief that context awareness has the potential to supplement the Internet of Things, when a suitable methodology including supporting tools will ease the development of context-aware applications. We believe that a meta-model based approach can be key to achieving this goal. In this paper, we present our meta-model based methodology, which allows us to define and build application-specific context models and the integration of sensor data without any programming. We describe how that methodology is applied with the implementation of a relatively simple context-aware COVID-safe navigation app. The outcome showed that programmers with no experience in context-awareness were able to understand the concepts easily and were able to effectively use it after receiving a short training. Therefore, context-awareness is able to be implemented within a short amount of time. We conclude that this can also be the case for the development of other context-aware applications, which have the same context-awareness characteristics. We have also identified further optimization potential, which we will discuss at the conclusion of this article

The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin

International audienceThe major opportunistic pathogen Staphylococcus aureus utilizes the human fibrinolytic system for invasion and spread via plasmin(ogen) binding and non-proteolytic activation. Because S. aureus secretes several proteases recently proposed as virulence factors, we explored whether these enzymes could add to the activation of the host's fibrinolytic system. Exposure of human pro-urokinase (pro-uPA) to conditioned growth media from staphylococcal reference strains results in an EDTA-sensitive conversion of the single-chain zymogen into its two-chain active form, an activity not observed in an aureolysin-deficient strain. Using purified aureolysin, we verified the capacity of this thermolysin-like metalloprotease to activate pro-uPA, with a 2.6 x 10 3}M -1}s -1} catalytic efficiency. Moreover, activation also occurs in the presence of human plasma, as well as in conditioned growth media from clinical isolates. Finally, we establish that aureolysin (i) converts plasminogen into angiostatin and mini-plasminogen, the latter retaining its capacity to be activated by uPA and to hydrolyze fibrin, (ii) degrades the plasminogen activator inhibitor-1, and (iii) abrogates the inhibitory activity of α 2}-antiplasmin. Altogether, we propose that, in parallel to the staphylokinase-dependent activation of plasminogen, aureolysin may contribute significantly to the activation of the fibrinolytic system by S. aureus, and thus may promote bacterial spread and invasion

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31â127 anaesthetic procedures in 30â874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0â5·5) with an incidence of respiratory critical events of 3·1% (2·9â3·3). Cardiovascular instability occurred in 1·9% (1·7â2·1), with an immediate poor outcome in 5·4% (3·7â7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10â000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86â0·90; p<0·0001), medical history, and physical condition (1·60, 1·40â1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981â0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97â0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia. Funding European Society of Anaesthesiology

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for cardiovascular critical events), rather than the type of health institution or providers. Interpretation This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia